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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PTPN11
All Species:
20.91
Human Site:
S562
Identified Species:
46
UniProt:
Q06124
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.2
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q06124
NP_002825.3
597
68436
S562
D
Q
T
S
G
D
Q
S
P
L
P
P
C
T
P
Chimpanzee
Pan troglodytes
XP_001164543
512
58884
S477
D
Q
T
S
G
D
Q
S
P
L
P
P
C
T
P
Rhesus Macaque
Macaca mulatta
XP_001110915
597
67615
A554
M
K
N
A
H
A
K
A
S
R
T
S
S
K
H
Dog
Lupus familis
XP_534686
571
65327
R537
E
E
E
Q
K
S
K
R
K
G
H
E
Y
T
N
Cat
Felis silvestris
Mouse
Mus musculus
P35235
597
68442
S562
D
Q
T
S
G
D
Q
S
P
L
P
P
C
T
P
Rat
Rattus norvegicus
P41499
597
68440
S562
D
Q
T
S
G
D
Q
S
P
L
P
P
C
T
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519242
359
41028
T325
P
K
K
S
Y
I
A
T
Q
G
C
L
Q
N
T
Chicken
Gallus gallus
Q90687
593
67964
S558
D
Q
T
S
G
D
Q
S
P
L
P
P
C
T
P
Frog
Xenopus laevis
NP_001084076
595
68232
L558
E
Q
G
D
Q
S
P
L
P
P
C
T
P
T
P
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P29349
845
92957
S682
I
G
N
D
S
Q
R
S
P
L
P
P
A
I
S
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784121
533
60826
K499
P
A
I
L
N
E
D
K
N
V
Y
Q
N
V
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
85.7
54
95.1
N.A.
99.5
98.9
N.A.
59.2
97.6
93.4
N.A.
N.A.
38.5
N.A.
N.A.
51.9
Protein Similarity:
100
85.7
70
95.1
N.A.
99.8
99.5
N.A.
60.1
98.4
95.8
N.A.
N.A.
51.3
N.A.
N.A.
65.8
P-Site Identity:
100
100
0
6.6
N.A.
100
100
N.A.
6.6
100
26.6
N.A.
N.A.
33.3
N.A.
N.A.
0
P-Site Similarity:
100
100
26.6
26.6
N.A.
100
100
N.A.
20
100
33.3
N.A.
N.A.
40
N.A.
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
10
0
10
0
10
10
10
0
0
0
0
10
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
19
0
46
0
0
% C
% Asp:
46
0
0
19
0
46
10
0
0
0
0
0
0
0
0
% D
% Glu:
19
10
10
0
0
10
0
0
0
0
0
10
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
10
10
0
46
0
0
0
0
19
0
0
0
0
10
% G
% His:
0
0
0
0
10
0
0
0
0
0
10
0
0
0
10
% H
% Ile:
10
0
10
0
0
10
0
0
0
0
0
0
0
10
0
% I
% Lys:
0
19
10
0
10
0
19
10
10
0
0
0
0
10
0
% K
% Leu:
0
0
0
10
0
0
0
10
0
55
0
10
0
0
0
% L
% Met:
10
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
19
0
10
0
0
0
10
0
0
0
10
10
10
% N
% Pro:
19
0
0
0
0
0
10
0
64
10
55
55
10
0
55
% P
% Gln:
0
55
0
10
10
10
46
0
10
0
0
10
10
0
0
% Q
% Arg:
0
0
0
0
0
0
10
10
0
10
0
0
0
0
0
% R
% Ser:
0
0
0
55
10
19
0
55
10
0
0
10
10
0
10
% S
% Thr:
0
0
46
0
0
0
0
10
0
0
10
10
0
64
10
% T
% Val:
0
0
0
0
0
0
0
0
0
10
0
0
0
10
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
10
0
0
0
0
0
10
0
10
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _